The game of tic tac toe is not useful for every medical situation. This paper makes that clear:
“Tic-tac-toe does not provide lessons for appreciating the HLA–rheumatoid arthritis relationship: Comment on the editorial by Bridges et al.,” A.H.M. van der Helm-van Mil, T. W. J. Huizinga, R.R.P. de Vries, and R.E.M. Toes, Arthritis and Rheumatism, vol. 58, no. 11, 2008, p. 3635.
BONUS: This photo shows a pediatric neurosurgeon —Dr. Joseph Madsen of Boston Children’s Hospital, assisted by neurosurgical operating room nurse Judie Jackson) — engaged in a game of tic tac toe at the 2016 Ig Nobel Prize ceremony. (Details are in the special 2016 Ig Nobel issue of the magazine.) The photo was taken by Howard I. Cannon: